INCYPRO

Structure-guided chemical protein stabilization. 

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Why is stability the key to protein performance?

Proteins are powerful yet fragile constructs. In today’s therapeutic and industrial settings, many proteins lose their structure during manufacturing, storage,        or administration. This leads to aggregation, short half-life,                                        and inconsistent performance.

A smarter way to strengthen proteins.

We believe better proteins start with respecting natural protein structures, rather than redesigning them. INCYPRO strengthens therapeutic proteins at the core, using precise covalent modifications to reinforce their structure. No bulky polymers. No disruptive redesigns. Just smarter engineering that keeps proteins stable under real-world stress; thermal, chemical, or biological.

Beyond Sequence Tweaks: True Structural Stabilization

Benefits of INCYPRO stabilization

Enhanced stability

Maintains functional conformation at elevated temperatures and in the presence of denaturants.

Prolonged activity

INCYPRO stabilization leads to longer enzymatic activities, up to 25 days longer.

Extended half-life

In preclinical studies, INCYPRO-modified proteins have demonstrated up to 20-fold increases in serum persistence

Reduced aggregation

Prevents dissociation and/or misfolding over extended time periods.

How it works

Computational site selection

Our AI-supported INCYPROsitefinder algorithm analyzes the protein’s 3D structure to identify optimal cysteine positions for crosslinking. These sites are chosen to support the active conformation while avoiding critical binding regions.

INCRYPRO crosslinkers

A panel of tris-armed crosslinkers offer different reactivities, linker lengths, and hydrophilicity. These small molecules lead to only minimal modification of the protein.

Covalent modification

The designed triple-cysteine protein variant is reacted with the crosslinker, selectively producing a defined INCYPRO protein and effectively stabilizing the protein.

Accessing INCYPRO

We collaborate with partners to apply INCYPRO across therapeutic and industrial applications. Engagement options include:

Feasibility Studies

Assess the impact of INCYPRO stabilization on your target protein under relevant conditions.

Long-term partnerships

From co-development agreements to full technology transfer, we support the advancement of stabilized biologics.

Whether you’re modifying a protein or creating a new one – INCYPRO helps you do it better

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